Mechanism of Action:
Pregabalin
- Pregabalin binds to the alpha-2-delta () subunit of voltage-gated calcium channels in the central nervous system.
- This binding reduces calcium influx into nerve terminals, which decreases the release of excitatory neurotransmitters such as glutamate, norepinephrine, serotonin, substance P, and others.
- By reducing neurotransmitter release, pregabalin lowers neuronal excitability and alleviates neuropathic pain and seizures.
- Although structurally related to GABA, pregabalin does not act on GABA receptors directly, nor does it block calcium channels like traditional calcium channel blockers.
Methylcobalamin: Methylcobalamin is active form o f vitamin B12 which played a key role i n the normal functioning of the brain and nervous system. It can directly participate in homocysteine metabolism. Methylcobalamin exerts its therapeutic effects on neuropathic pain through its neuro-synthesis and neuro-protective actions. The fixed dose combination of Pregabalin 75 mg + Methylcobalamin 750 mcg capsules is approved by DCGI for the treatment of adult patients with peripheral neuropathy.
PREGACELL / PREGACELL M is indicated for:
Neuropathic pain management, including pain caused by nerve damage or neuropathy.
Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
Postherpetic neuralgia (PHN)
Adjunctive therapy for adult patients with partial onset seizures
Fibromyalgia
Neuropathic pain associated with spinal cord injury
Pregabalin with Methylcobalamin clinical advantages include:
- Dual action for neuropathic pain relief: Pregabalin calms overactive nerves reducing pain signals, while methylcobalamin supports nerve repair and regeneration by promoting myelin sheath formation and neurite outgrowth.
- Effective in treating diabetic neuropathy, sciatica, chronic back pain, and other nerve-related conditions by relieving pain and restoring nerve function.
- Improves symptoms like tingling, numbness, and burning sensations more comprehensively than either agent alone.
- Enhances quality of life by improving sleep, mobility, and daily activities impaired by nerve pain.
- May prevent further nerve damage with regular use under supervision by addressing underlying nerve pathology, not just symptoms.
- Fewer side effects and better tolerability when combined than some other neuropathic pain regimens.
- Supported by clinical studies showing significant pain reduction, improved nerve conduction, and overall nerve health restoration.
This combination is widely prescribed for nerve pain and neuropathy due to its synergistic pharmacological effects—calming nerve hyperactivity while promoting nerve healing and protection—offering both symptomatic relief and disease-modifying potential.
