Mechanism of Action:
Pregabalin
- Pregabalin binds to the alpha-2-delta () subunit of voltage-gated calcium channels in the central nervous system.
- This binding reduces calcium influx into nerve terminals, which decreases the release of excitatory neurotransmitters such as glutamate, norepinephrine, serotonin, substance P, and others.
- By reducing neurotransmitter release, pregabalin lowers neuronal excitability and alleviates neuropathic pain and seizures.
- Although structurally related to GABA, pregabalin does not act on GABA receptors directly, nor does it block calcium channels like traditional calcium channel blockers.
Pregacell is indicated for:
- Neuropathic pain management, including pain caused by nerve damage or neuropathy.
- Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
- Postherpetic neuralgia (PHN)
- Adjunctive therapy for adult patients with partial onset seizures
- Fibromyalgia
- Neuropathic pain associated with spinal cord injury
